2425 Detection of inducible nitric oxide synthase (INOS) in experimental autoimmune uveoretinitis (EAU) corresponds with enhanced expression of interferon-γ

m We have su~ested a role for nitric oxide as a mediir of the autoimmune dcattuaion of tbe retina in our rat model of EAU. ln orevious immunohktochanical studies we detected the iNOS enzyme only dkng and at the site of active disease, c&xalising’tith activated ED1 positive macrophages intiltrating the retina. The ah of this study was to detect iNOS mRNA and investigate the eqreasion of intlammatory cytokines, knovm to be important In the hlducti0r1 of iNos in vifro, in diseased eyes throughout progression of EAU.